Gastro-retentive drug delivery systems (GRDDS) have emerged as a promising approach to enhance the bioavailability of drugs exhibiting a narrow absorption window in the upper gastrointestinal tract. Telmisartan, an angiotensin II receptor antagonist with low aqueous solubility and variable oral bioavailability, is an ideal candidate for gastro-retentive formulation. The present research focuses on the pharmaceutical development and in-vitro evaluation of effervescent gastro-retentive floating tablets of Telmisartan prepared by direct compression technique. Floating tablets were formulated using hydrophilic polymers and gas-generating agents to achieve prolonged gastric residence time and sustained drug release. Pre-compression and post-compression parameters were evaluated to ensure acceptable flow, compressibility, mechanical strength, buoyancy, and drug content uniformity. In-vitro buoyancy and dissolution studies demonstrated rapid floating lag time, prolonged floating duration, and controlled drug release up to 12 hours. The study confirms that gastro-retentive floating tablets of Telmisartan can be successfully developed to enhance gastric retention and potentially improve bioavailability.
Telmisartan, gastro-retentive drug delivery system, floating tablets, hypertension, sustained release.
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